We develop and apply new computational modelling tools to design proteins with novel properties. In particular, we are interested in a family of proteins forming beta-sheet in lipid membranes: transmembrane beta-barrels (TMBs). TMBs form stable and rigid pores through the lipid bilayer and are excellent scaffolds for the engineering of nanopore sensors and transmembrane channels. We use de novo design (for hypothesis testing) and high-throughput experiments to study the fundamental principles of TMB folding in lipid membranes. Our end goal is to develop an interdisciplinary TMB design platform integrating computational design and experimental characterisation, to enable the design of selective nanopores and gated channels for sensing and synthetic biology applications. We work with the Rosetta macromolecular modelling software and we are members of the RosettaCommons community.